正确理解“精准医学”在临床实践中的意义

2015年初在美国正式提出一个在研究基因序列的基础上,探索疾病的根源,预防和治疗的规划并被定名为Precision medicine,译称精确医学或精准医学。该定义在临床医生中引起了不同的意见和疑虑,因为这涉及到临床医学研究和实践中的导向问题。精准医学应该是对医学服务的一种要求,要求医学服务从行为和方法上达到精准,以基因序列和表达调控为基础的分子医学是狭义的精准医学,与临床医学所要求的精准相互关联又有所不同。临床工作者直接面对大多数病人,须要运用符合现代医学认可的各种各样的方法(包括基因系列的成果)解决病人的问题,而不管这种方法是否基于基因分析的结果。这种以循证医学为基础的临床医学属广义的精准医学。

Significance of a good comprehension of'precision medicine'in clinical practice

【Abstract】 To discover the cause of diseases and improve prevention and treatment, a program initiating by the study of genetic sequence alteration was launched in January last year in US. It is named as precision medicine. This definition of precision medicine resulted in certain confusion and frustration among clinicians, which would fundamentally influent the trends and future directions of medicine re-search and practice. In fact, clinicians have already borne their own concept of precision medicine based on the definition of evidence based medicine. These two definitions are relative, but not complete the same. Understanding the meaning of precision medicine is a must or essential for clinical practice. Clini-cians must use all modern methods of treatment precisely for their patients regardless of whether they meet the standards of molecular genetic study or not. The criteria of precision medicine have a much more generalized meaning for clinicians.