DNA损伤修复基因XRCC1 Arg194Trp基因多态性与中国人群结直肠癌易感性的Meta分析

【摘要】 目的 探讨DNA损伤修复基因XRCC1 Arg194Trp基因多态性与中国人群结直肠癌易感性的关系。方法 按照制定的检索策略,通过计算机和手工检索相关数据库,收集有关XRCC1 Arg194Trp基因多态性与中国人群结直肠癌易感性的病例对照研究,按照纳入标准筛选文献、并从纳入文献中提取相关数据,以病例组和对照组基因型分布的比值比(OR)为效应指标,应用Stata12.0软件进行异质性检验,对各研究原始数据进行Meta合并,并行敏感性分析和发表偏倚的评估。结果〓本Meta分析共纳入11项病例对照研究,累积病例2710例,对照3567例。根据各研究间的异质性,采用不同的模型进行合并效应量。在等位基因比较(T vs C) [OR(95%CI)=1.18(1.01-1.39),P=0.036],纯合子比较模型(TT vs CC) [OR (95%CI)=1.39(1.02-1.90),P=0.038],显性模型(CT/TT vs CC) [OR(95%CI)=2.24(1.78-2.82),P<0.001] 以及隐性模型 (TT vs CT/CC) [OR(95%CI)=1.23(1.02-1.49),P=0.030]均存在显著的统计学差异。发表偏倚评估均未见明显偏倚。结论〓在中国人群中,携带突变等位基因T或突变纯合子TT的人群罹患CRC的风险有所升高,而在显性遗传模型中,携带有CT/TT基因型的人群其CRC的易感性明显升高。

Meta -analysis of the correlation between XRCC1 Arg194Trp polymorphism and genetic susceptibility of colorectal cancer

Objective To explore the relationship between the polymorphism of X-ray cross complementing group 1 (XRCC1) Arg194Trp and genetic susceptibility of colorectal cancer (CRC). Methods All eligible case-control studies on the relationship between the polymorphism of the XRCC1 Arg194Trp and CRC in Chinese population were searched in both English and Chinese databases. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. All analyses were conducted in Stata 12.0. Results A total of 11 case-control studies with 2710 cases and 3567 controls on XRCC1 Arg194Trp were included the Meta-analysis, and significant increased risks were found in additive models [(T vs C): OR (95%CI)=1.18 (1.01-1.39), P=0.036], homozygote comparison [(TT vs CC): OR (95%CI) =1.39 (1.02-1.90), P=0.038], Dominant models [(CT/TT vs CC): OR (95%CI) =2.24 (1.78-2.82), P<0.001], and recessive models [(TT vs CT/CC): OR (95%CI)=1.23 (1.02-1.49), P=0.030]. No publication bias was found in all genetic model. Conclusion In Chinese population, individuals carrying mutation allele T or homozygous mutation TT may have an increased risk of developing CRC, furthermore, individuals with the CT/TT genotype significantly increased the risk of suffering from CRC.