PSA密度在PSA 2.5～10.0 ng/mL和10.1～20.0 ng/mL患者前列腺癌诊断价值的多中心研究

目的探讨前列腺特异性抗原密度(PSAD)在前列腺特异性抗原(PSA)值位于2.5~10 ng/m L和10.1~20.0 ng/m L患者前列腺癌诊断的效能。方法回顾性分析广州地区两家医院中PSA在2.5~20.0 ng/m L之间,行经直肠前列腺体积测量并行前列腺穿刺的461名患者临床资料,入选者分为PSA 2.5~10.0 ng/m L和PSA10.1~20.0 ng/m L两组,通过受试者工作特征曲线(ROC)分析法评价PSAD与PSA在预测前列腺癌的诊断效力。结果 PSA 2.5~10.0 ng/m L和PSA 10.1~20.0 ng/ml两组的曲线下面积比较,PSAD均高于PSA。在PSA 2.5~10.0 ng/m L组,PSAD预测前列腺癌的最佳临界点为0.15 ng·m L~(-1)·m L~(-1),敏感性和特异性分别为64.4%和64.6%;在PSA10.1~20.0 ng/m L组,PSAD预测前列腺癌的最佳临界点为0.33 ng·m L~(-1)·m L~(-1),敏感性和特异性分别为60.3%和82.7%。结论对于PSA2.5~10.0 ng/m L和10.1~20.0 ng/m L的中国男性,PSAD是一种更优的前列腺癌预测指标。

Significance of PSA density for detecting prostate cancer in Paients with a PSA between 2.5-10.0 ng/ml and 10.1-20.0 ng/ml:a multicenter study

【Abstract】〓Objective〓To investigate the significance of prostate-specific antigen density (PSAD) for detecting prostate cancer in patients with a PSA between 2.5-10.0 ng/ml and 10.1-20.0 ng/ml. Methods〓461 men with a PSA between 2.5-20.0 ng/ml, underwent prostatic biopsy at two centers in Guangzhou, were retrospectively studied, and were divided into two groups (PSA 2.5-10.0 ng/ml vs. PSA10.1-20.0 ng/ml). Receiver operating characteristic (ROC) curve was used to evaluate the efficacy of PSA and PSAD for the diagnosis. Results〓In men with a PSA of 2.5-10.0 or 10.1-20.0 ng/ml, the areas under the ROC curve (AUCs) were higher for PSAD than for PSA. The optimal PSAD cut-off for predicting prostate cancer in men with a PSA of 2.5-10.0 ng/ml was 0.15 ng/ml/ml, with a sensitivity of 64.4% and specificity of 64.6%. The optimal cut-off for PSAD in men with a PSA of 10.1-20.0 ng/ml was 0.33 ng·ml-1·ml-1,with a sensitivity of 60.3% and specificity of 82.7%. Conclusion〓PSAD is illuminated a predictor of prostate cancer in patients with PSA between 2.5-10.0 ng/ml and 10.1-20.0 ng/ml.