舒芬太尼与芬太尼对婴儿麻醉苏醒期镇痛的比较

目的观察静脉给予舒芬太尼与芬太尼对婴儿麻醉苏醒期镇痛的影响。方法选取90例儿外科手术患儿,年龄1个月~1岁(其中年龄最小者1.5个月,最大者11.5个月),随机分为舒芬太尼组(S组)与芬太尼组(F组),每组45例,S组给予舒芬太尼0.1μg/kg静脉注射,F组给予芬太尼1μg/kg静脉注射,观察两组给药后5、10、30、60 min的镇痛、镇静评分及呼吸、循环、恶心呕吐的变化。结果 S组与F组在给药5、10 min的镇痛镇静评分比较差异无统计学意义(P>0.05),在给药30、60 min时间点比较,S组镇痛镇静评分明显高于F组,差异有统计学意义(P<0.05),两组患儿均未出现呼吸暂停及呼吸节律改变,Sp O2均未低于95%,心率、血压未见明显改变,未出现苏醒延迟,S组有1例轻度恶心,F组有2例轻度恶心。结论与芬太尼比较,术后给予婴儿舒芬太尼能起到良好的镇痛和镇静效果,无呼吸、循环抑制,无苏醒期延迟等不良反应。

Comparison of analgesia effect of sufentanil and fentanyl on anesthesia recovery in infants

Objective To observe the effect of intravenous sufentanil and fentanyl analgesia on infant in anes-thesia recovery period. Methods Ninety infants aged 1 month to 1 year old ( the minimum age was 1. 5 months,the maximum age was 11. 5 months)were randomly divided into two groups:sufentanil group( group S)and fentanyl group( group F),45 infants in each group. Group S:sufentanil 0. 1 μg/kg iv,group F:fentanyl 1 μg/kg. The changes at 5,10,30,60 minutes of analgesia,sedation score and breathing,circulation,nausea and vomiting after drug adminis-tration were observed. Results No significant difference was found in analgesia sedation score of group S and group F at 5 minutes and 10 minutes( P﹥0. 05). Analgesia and sedation score of group S was significantly higher than that of group F in the administration of 30 minutes and 60 minutes,the difference was significant( P﹤0. 05). The two groups did not appear apnea and respiratory rhythm changes,SpO2 was not less than 95%. There were no significant changes in heart rate and blood pressure. There was no delayed recovery. In group S there was 1 patient with mild nausea,and group F there were 2 patients with mild nausea. Conclusion Compared with fentanyl,postoperative sufentanil plays a good analgesic and sedative effect,and there is no breathing and circulation inhibition or recovery period delay or other side effects.