Bowen病的临床与病理分析

目的 探讨Bowen病的临床、病理学特征以及细胞凋亡与其发病的关系。方法 收集16例Bowen病患者资料，观察和分析其临床和组织病理学特征，并通过免疫组化方法分析其p53、bcl-2及P-gP的表达。结果 Bowen病是一种皮肤原位癌，典型皮损为略隆起的暗红色持久性斑块。表面可有鳞屑或结痴，组织病理以表皮内各层细胞见较多异形细胞，基底层完整，首选手术治疗、长期随访。16例Bowen病均有一定程度的D53、bcl-2和P-gp的阳性表达，且均显著高于正常对照组（P〈0．05）。结论 Bowen病为低恶性的皮肤肿瘤，有特殊的，临床及组织病理特点，其肿瘤的发生、发展、预后可能与细胞凋亡有关。

Clinical and pathological features of Bowen''''s disease

[Objective] To study the clinical and pathological features,and the relation of apoptosis and pathogenesis of Bowen's disease.[Methods] Sixteen patients with BD were collected,and their clinical features were analyzed with pathological aspects observed by immunohistochemical SP techniques.[Results] The typical lesions of Bowen's disease are well defined erythematus patch covered with crusting and erosions.Histological examination showed that atypical cells were seen at all levels of the epidermis.Wide excision of the lesions is the first choice of treatment for BD.The expression levels of p53,bcl-2 and P-gp were all higher than controls(P <0.05).[Conclusions] BD is a malignant skin tumor with typical clinical and pathological features.Immunohistochemical analysis suggested that the pathogenesis and prognosis of BD may be related to apoptosis of epidermal keratinocytes.