| Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor-1 in Human Meningiomas |
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| 作者姓名： | 易伟 陈坚 FilimonH.Golwa 薛德麟 |
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| 作者单位： | DepartmentofNeurosurgery,TongjiHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,China |
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| 摘 要： | The expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in human meningiomas and the relationships between their expression and the tumors‘ histological features and angiogenesis were investigated by means of immunohistochemical technique. The expression of bFGF and FGFR-1 was detected by antibody of bFGF or FGFR-1.The tumors‘ angiogenesis was evaluated by microvascular density (MVD) and, which was observed by use of CD34-antibody immunohistochemically. The results showed that there were varied degrees of the expression of bFGF and FGFR-1 proteins in meningiomas. The expression was correlated with the tumors‘ histological characters and angiogenesis. It was concluded that bFGF and FGFR-1 might play important roles in meningiomas‘ angiogenesis and proliferation. The expression positive rate of bFGF and FGFR-1 may provide an indication of evaluating the histological and malignant degree of the tumor.
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| 关 键 词： | 碱性纤维原细胞生长因子 纤维原细胞生长因子受体-1 脑膜瘤 基因表达 |
| 收稿时间： | 20 March 2003 |
Basic fibroblast growth factor and fibroblast growth factor receptor-1 in human meningiomas |
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| Yi Wei,Chen Jian,Filimon H. Golwa,Xue Delin.Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor-1 in Human Meningiomas[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2005,25(1):75-77. |
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| Authors: | Yi Wei Chen Jian Filimon H Golwa Xue Delin |
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| Institution: | Department of Neurosurgery , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China |
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| Abstract: | The expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in human meningiomas and the relationships between their expression and the tumors' histological features and angiogenesis were investigated by means of immunohistochemical technique. The expression of bFGF and FGFR-1 was detected by antibody of bFGF or FGFR-1. The tumors' angiogenesis was evaluated by microvascular density (MVD) and, which was observed by use of CD34-antibody immunohistochemically. The results showed that there were varied degrees of the expression of bFGF and FGFR-1 proteins in meningiomas. The expression was correlated with the tumors' histological characters and angiogenesis. It was concluded that bFGF and FGFR-1 might play important roles in meningiomas' angiogenesis and proliferation. The expression positive rate of bFGF and FGFR-1 may provide an indication of evaluating the histological and malignant degree of the tumor. |
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| Keywords: | meningiomas basic fibroblast growth factor fibroblast growth factor receptor-1 microvascular density immunohistochemistry |
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