Sulfadiazine therapy for toxoplasmosis in heart transplant recipients decreases cyclosporine concentration |
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| Authors: | C. H. Spes C. E. Angermann H. U. Stempfle K. Wenke K. Theisen |
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| Affiliation: | (1) Herzchirurgische Klinik, Klinikum Großhadern, Ludwig-Maximilians-Universität, München, Germany;(2) Medizinische Klinik, Klinikum Innenstadt Ludwigs-Maximilians-Universität München, Ziemssenstrasse 1, W-8000 München 2, Germany |
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| Abstract: | Summary Toxoplasmosis may cause serious problems after organ transplantation. For treatment of active infection, pyrimethamine combined with a sulfonamide is recommended. During oral sulfadiazine therapy, a significant decrease in cyclosporine concentrations was observed in three heart transplant recipients. This interaction has not been reported previously. |
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| Keywords: | Cyclosporine Sulfadiazine Pharmacological interaction Toxoplasmosis Heart transplantation |
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