氟马西尼治疗苯二氮卓类药物混合乙醇中毒的疗效观察

目的：观察氟马西尼治疗苯二氮卓类药物混合乙醇中毒的临床疗效。方法：选择2011-06-2013-06我院急诊科接诊的苯二氮卓类药物混合乙醇急性中毒的58例患者,以Glasgow昏迷评分法（Glasgow Coma Scale,GCS）作为随机区组分配的非处理因素将受试对象分为治疗组与对照组。两组在常规处理的干预下,治疗组应用氟马西尼联合纳洛酮与醒脑静治疗,对照组应用纳洛酮与醒脑静救治。结果：治疗组在治疗后30min、60min、180min,三个时间点上的Glasgow得分以及治疗30min时MOAA/S（Modified Observers Assessment of Alertness/Sedation）得分均高于对照组,差异具有统计学意义（P〈0.05）,同时治疗组意识改变时间和急诊科治疗总时间均短于对照组,差异具有统计学意义（P〈0.05）;治疗组轻微不良反应发生率为25.9%,对照组轻微不良反应发生率为35.5%,两组差异无统计学意义,尚不能认为治疗组不良反应发生率少于对照组。治疗组并发症发生率为14.8%,对照组为41.9%,治疗组结果低于对照组,差异有统计学意义（P〈0.05）。结论：氟马西尼治疗苯二氮卓类药物混合乙醇中毒疗效显著,临床治疗时可给予应用。

Clinical observation of flumazenill combined with naloxone in the treatment of benzodiazepines mixed alcohol poisoning

Objective：To observe the clinical effect of flumazenill in the treatment of benzodiazepines mixed alcohol poisoning.Method：58cases of benzodiazepines mixed ethanol poisoning who were treated in our hospital from June 2011to June 2013were enrolled in the study.Taking GCS（Glasgow Coma Scale）as the non-treatment factors,the 58patients were randomized assigned into the treatment group and the control group.Both groups took the general treatment,while the treatment group use naloxone combined with flumazenill and Xingnaojing,the control group were given naloxone and Xingnaojing.Result：Compared with the control group,Glasgow score in the 30 min,60min,180min,and MOAA/S score in 30min were higher in the treatment group.The consciousness recovery time and the total treatment time were all shorter than those of control group.There were significant differences between the two groups（P〈0.05）.The slight adverse reaction rate in the treatment group was 25.9%,the control group was 35.5%,and there was no statistically significant difference.Complications in the treatment group was 14.8% and in control group was 41.9%.The results of treatment group was lower than the control group,the difference was statistically significant（P〈0.05）.Conclusion：The clinical effect of flumazenill in the treatment of benzodiazepines mixed alcohol poisoning was significant.Flumazenill can be applied in clinical treatment.