急性乙醇中毒与超敏C反应蛋白水平的相关性研究

目的：探讨急性乙醇中毒患者血液乙醇浓度（BAC）与超敏C反应蛋白（hs-CRP）水平的关系,分析BAC与hs-CRP水平的相关性。方法：分成急性乙醇中毒组（AL组）90例、对照组（NC组）30例,其中根据乙醇中毒程度及BAC值不同AL组又分为AL-Ⅰ组（轻度中毒）（BAC〈200mg/L）,AL-Ⅱ组（中度中毒）（200mg/L≤BAC〈800mg/L）,AL-Ⅲ组（重度中毒）（BAC≥800mg/L）,每组30例,检测各组的hs-CRP浓度,并与NC组对照。分析BAC与hs-CRP浓度的相关性。结果：对照组与AL-Ⅰ组之间hs-CRP浓度差异无统计学意义（P〉0.05）。其他各组两两之间的差异有统计学意义（P〈0.05）。AL-Ⅰ组BAC与hs-CRP浓度无相关性（P〉0.05）,AL-Ⅱ组、AL-Ⅲ组BAC与hs-CRP浓度呈正相关（P〈0.05）。结论：急性乙醇中毒轻度以上患者的BAC与hs-CRP浓度呈正相关,对于急性乙醇中毒患者hs-CRP是一项具有临床价值的检测项目。

The clinical research of the relationship between acute alcoholism and high sensitive C-reactive protein

Objective： To investigate the effect of the acute alcoholism on the serum high sensitive c-reactive protein （hs CRP） and analyze the correlation between the hs CRP and the blood Alcohol Concentration（BAC）. Method： 120 cases were divided into acute alcoholism group （AL group）including 90 cases of patients with acute al coholism and the control group （NC group） including 30 persons. Air group were averagly divided into AI. group（BAC〈200 mg/L）,AL-Ⅱ group（200 mg/L≤BAC〈800 mg/L）,AL-Ⅲ group（BAC≤800 mg/L）. The hs-CRP concentration were tested. The correlation of BAC and hs-CRP were analyzed. Result：No significant difference was found between control group and AL-I group about the hs-CRP levels （P〉0.05）. The difference of the rest groups between the two had statistically significance （P〈0.05）. The BAC of ALI group showed no correlation with the hs CRP levels （P〉0.05）. The BAC of AL-Ⅱ group and AL-Ⅲ group were positively related to the hs CRP levels （P〈0.05）. Conclusion：There was significant correlation between the BAC（BAC≥200 mg/L）and the hs-CRP. The hs-CRP had clinical value for the patients with acute alcoholism.