| 眼肌结合抗体的ELISA检测及应用 |
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| 引用本文： | 王艾丽 于利凌. 眼肌结合抗体的ELISA检测及应用[J]. 中国免疫学杂志, 1996, 12(1): 34-36 |
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| 作者姓名： | 王艾丽 于利凌 |
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| 作者单位： | 南京军区南京总医院临床免疫科!南京210002(王艾丽，武建国)，山东省济宁市市中区人民医院检验科!济宁272100(于利凌)，南京军区南京总医院内分泌实验室!南京219002(冯根宝) |
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| 摘 要： | 自猪和牛眼肌提取眼肌抗原，建立了检测人血清中眼肌结合抗体（ＥＭ－Ａｂ）的ＥＬＩＳＡ法。检测４０例甲亢患者阳性率为３０．０％，２３例ＳＬＥ患者阳性率为２６．９％，与正常对照组比较有显著差别（Ｐ〈０．０１）。ＥＭ－Ａｂ与甲状腺疾病的一些自身抗体无显著相关性，提示此是与眼病自身免疫反应有关的一种自身抗体。
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| 关 键 词： | 眼肌结合抗体 ELISA 自身免疫性 眼病 |
DETECTION OF EYE-MUSCLE BINDING ANTIBODY BY ELISA |
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| Wang Aili,Yu Liling,Wu Jianguo et al.. DETECTION OF EYE-MUSCLE BINDING ANTIBODY BY ELISA[J]. Chinese Journal of Immunology, 1996, 12(1): 34-36 |
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| Authors: | Wang Aili Yu Liling Wu Jianguo et al. |
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| Abstract: | The eye-muscle binding antibody (EM-Ab) in human serum was detected by ELISA with two antigens prepared from fresh big and bovine orbital muscles. The positive rates of EM-Ab in hyperthyroid and systemic lupus erythematosus(SLE) patients were 30. 0% (12/ 40) and 26. 9% (6/23)respectively and were significantly different compared with healthy subjects (P <0. 01). There was no correlation between EM-Ab and some antibodies against thyroid. It was suggested that the eye-muscle binding antibody might present an autoantibody associated with autoimmune ophthalmopathy. |
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| Keywords: | Eye-muscle binding antibody ELISA Autoimmune ophthalmopathy |
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