Treatment of severe lichen planus with mycophenolate mofetil |
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Authors: | Frieling Uta Bonsmann Gisela Schwarz Thomas Luger Thomas A Beissert Stefan |
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Institution: | Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, Germany. |
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Abstract: | Lichen planus (LP) is an inflammatory skin disorder with a wide range of clinical appearances. The treatment of disseminated and especially erosive forms of LP is often difficult and disappointing. Activated T cells are important in the pathogenesis of LP as indicated by the dermal lymphocytic infiltrate leading to keratinocyte destruction and lesion formation. Similar histologic findings are present in graft-versus-host disease. Since T cells are key players in the development of both disorders and mycophenolate mofetil has been successfully introduced in the treatment of graft-versus-host disease, we have examined the therapeutic potential of this agent in 3 patients suffering from disseminated and erosive LP. Mycophenolate mofetil was well tolerated and induced complete remission in 2 patients, and substantial improvement in the third patient. |
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