首页 | 本学科首页   官方微博 | 高级检索  
     


Involvement of tumor necrosis factor-α and interleukin-8 in antigen-induced arthritis of the rabbit temporomandibular joint
Authors:Miho Sukedai  Kazuhiro Tominaga  Manabu Habu  Akihiro Matsukawa  Tatsuji Nishihara  Jinichi Fukuda
Affiliation:First Department of Oral and Maxillofacial Surgery, Kyushu Dental College, 2-6-1 Manazuru, Kitakyushu 803-8580, Japan. miho-s@kyu-dent.ac.jp
Abstract:BACKGROUND: In temporomandibular joint (TMJ) arthritis, knowledge is limited about the source of the inflammatory mediators. The aim of this study was to investigate the immunohistochemical role of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) in the development of the antigen-induced arthritis of the rabbit TMJ. METHODS: Unilateral TMJ arthritis was induced in 28 adult rabbits. From 6 h to 6 weeks after induction of arthritis, the topology of TNF-alpha and IL-8 was observed. RESULTS: Positive reaction for TNF-alpha of synovial cells was observed within 3 days after induction and at 3 weeks after induction. TNF-alpha positive vascular endothelial cells and chondrocytes were identified throughout the observation period. IL-8 was detected only during the acute stage. CONCLUSIONS: The cytokines TNF-alpha and IL-8 were observed in specific cells depending on the stage. TNF-alpha was particularly related with angiogenesis and cartilage destruction and IL-8 was involved in the acute stage of inflammation.
Keywords:antigen-induced arthritis    immunohistochemistry    interleukin-8    rabbit    temporomandibular joint    tumor necrosis factor-α
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号