细胞间黏附分子-1在喉癌间质淋巴细胞中的表达及其临床意义

目的:探讨细胞间黏附分子1(ICAM1,CD54)在喉癌间质淋巴细胞中的表达及临床意义。方法:采用免疫组织化学SP法测定5例正常人喉组织、30例喉癌癌旁不典型增生组织和78例喉癌组织标本中ICAM1的表达。ICAM1主要定位于核膜,表达强度按阳性细胞数计算。结果:ICAM1主要表达于喉癌间质淋巴细胞核膜上,在正常人喉上皮、癌旁不典型增生及喉癌细胞中无表达。Ⅰ、Ⅱ期喉癌组织中淋巴细胞ICAM1的表达明显高于Ⅲ、Ⅳ期(P<0.05);伴颈淋巴结转移的喉癌组织淋巴细胞ICAM1表达明显低于无颈淋巴结转移者(P<0.05)。ICAM1高表达病例3、5年生存率明显高于ICAM1低表达者(P<0.05)。结论:喉癌组织中淋巴细胞ICAM1表达与喉癌的发展、转移及预后有关。

The expression of ICAM-1 in laryngeal carcinoma and it's significance

Objective:To study the expression of ICAM-1 in laryngeal carcinoma and it's significance.Method:ICAM-1 were detected in 78 cases laryngeal carcinoma, 30 cases dysplasia and 5 cases normal by SP immunohistochemistry.Result:ICAM-1 can be expressed on the lymphocytes of patients with laryngeal carcinoma, but not cells of normal, dysplasia and cancer.The first and second stages laryngeal carcinoma had stronger ICAM-1 expression than those of the third and fourth stages(P<0.05).ICAM-1 expression in laryngeal carcinoma with cervical metastasis was higher than that without cervical metastasis(P<0.05).Three and five years survival rate in patients with higher ICAM-1 expression were higher than those of patients with lower ICAM-1 expression (P<0.05).Conclusion:These results implicate that the development, metastasis and prognosis of laryngeal carcinoma may be correlated to ICAM-1 expression of lymphocyte.