18F]-Dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism. |
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| Authors: | Pramod K Pal Joanne Leung Katya Hedrich Ali Samii Abraham Lieberman Paul A Nausieda Donald B Calne Xandra O Breakefield Christine Klein A Jon Stoessl |
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| Institution: | Neurodegenerative Disorders Centre, Vancouver Hospital & Health Sciences Centre, University of British Columbia, Vancouver, British Columbia, Canada. |
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| Abstract: | There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of (18)F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene. |
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| Keywords: | parkin dopamine Parkinson's disease PET genetics |
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