脑胶质瘤中survivin蛋白表达情况及其与肿瘤恶化程度关系的研究

目的 探讨survivin蛋白在脑胶质瘤的表达情况及其与肿瘤恶性程度之间的关系.方法收集脑胶质瘤患者组织蜡块90例,其中Ⅰ级30例,Ⅱ级30例,Ⅲ级～Ⅳ级30例.另取10例因颅脑创伤行内减压的正常脑组织蜡块作为对照.应用免疫组织化学染色方法检测脑胶质瘤组织survivin蛋白的表达情况. 结果 胶质瘤细胞胞浆中有survivin蛋白的表达,且随着肿瘤级别的增高,survivin蛋白的表达增强.其表达阳性率在Ⅰ级组中为16.67%(6/30),在Ⅱ级组中为46.67%(14/30),在Ⅲ级～Ⅳ级组中为86.67%(26/30),差异有统计学意义(P<0.05).而在正常脑组织中survivin的表达为阴性. 结论 Survivin在脑胶质瘤的恶变过程中起重要作用,针对survivin的靶向治疗有望成为治疗脑胶质瘤的一个新的途径.

Study of survivin protein expression in gliomas and its correlation with malignancy of gliomas

Objective To explore the expression of survivin in gliomas and its clinical significance. Methods The immunohistochemistry was used to measure protein expression of survivin in 90 cases ofglioma with grade Ⅰ 30cases, gradeⅡ30 cases and gradeⅢ-Ⅳ30 cases. We also used ten normal immunohistochemistry slices resulted from decompression after traumatic brain injury as control group. Results There are survin protein expressions in glioma cytoplasm and the higher the malignancy is, the expression becomes higher. The positive rate of survivin was 16.67% with glioma grade Ⅰ(6/30), 46.67% with gradeⅡ (14/30), and 86.67 % with grade Ⅲ- Ⅳ(26/30) which had statistical significance. However, in normal cerebral tissue, the expression of survivin was negative. Conclusion Survivin expression in gliomas is related to themalignancy of the tumor and it's targeted therapy may become a new management for gliomas.