人脑梗死后星形胶质细胞反应和微血管标记物相关性的研究

目的探讨人脑梗死灶周围组织星形胶质细胞和微血管的变化。方法应用9例因脑梗死而死亡尸检全脑标本，常规HE和免疫组织化学染色（SP）标记星形胶质细胞中的胶质纤维酸性蛋白（GFAP）和微血管标记物（CD31），观察星形胶质细胞和微血管的变化规律。结果以梗死灶为中心，由内到外可分4个区（0～3区）；GFAP在0区和1区表达很少，在2区和3区随缺血时间延长表达持续升高；CD31在0区无表达，在1区可见少量表达，在2区和3区随缺血时间延长表达持续升高。结论脑梗死后星形胶质细胞和微血管反应性增生，在缺血后期GFAP、CD31广泛表达，两者在组织损伤修复重建过程中起重要作用。

Time-dependent changes of astrocytes and CD31-marked microvessels in human cerebral infarction

Objective To observe the time-dependent changes of astrocytes and microvessels in the ischemic core and surrounding areas.Methods Glial fibrillary acidic protein (GFAP)was measured by HE,and CD31 by immunohistochemistry as markers in post-mortem specimens from ten patients,who died of cerebral infarction.Results Each section of the infarcted brains was divided into four areas (the area 0-3).GFAP expressed a little in area 0 and 1,increased in a time-dependent manner in area 2 and 3;CD31 die not expressed in area 0,expressed a little in the area 1,and increased in area 2 and 3 continuously.Conclusions The proliferation of astrocytes and microvessels may play a significant role in the process of restoration after cerebral infarction.