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VIRUS TITRES AND PERSISTENTLY RAISED WHITE CELL COUNTS IN CEREBROSPINAL FLUID IN MICE AFTER PERIPHERAL INFECTION WITH DEMYELINATING SEMLIKI FOREST VIRUS |
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| Authors: | LINDA M. PARSONS H. E. WEBB |
| Affiliation: | Neurovirology Unit, Department of Neurology, The Rayne Institute, St Thomas's Hospital, London SE1 7EH |
| Abstract: | Parsons L.M. & Webb H.E.1982 Neuropathology and Applied Neurobiology 8, 395–401 Virus titres and persistently raised white cell counts in cerebrospinal fluid in mice after peripheral infection with demyelinating Semliki Forest virus Virus titres and cell counts in the cerebrospinal fluid of mice have been examined following intraperitoneal inoculation of demyelinating Semliki Forest virus (SFV). Virus titres in cerebrospinal fluid were highest 2–4 days after infection and fell again after day 4, 48 h before reduction in brain titres. White cell counts were very low in the first 48 h and showed a steep rise from 4 days after infection to a peak on day 6. After day 8, cell numbers fell to a plateau level which was sustained up to day 61. The significance of these findings in relation to the pathogenesis of virus-induced disease of the central nervous system is discussed. |
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