临产孕妇凝血指标的变化及其临床意义

目的:了解孕妇分娩前的凝血功能情况,探讨临产孕妇检测凝血酶原时间(prothrombin time,PT)、激活部分凝血活酶时间(activated partial thrombopastin time,APTT)、纤维蛋白原(fibrinogen,Fib)和D-二聚体(D-dimer)的临床意义。方法:检测35例足月临产孕妇和40名正常体检妇女PT、APTT、Fib、D-dimer。结果:临产孕妇与正常非孕妇女比较,PT差异无统计学意义(P>0.05),而APTT显著降低(P<0.05),Fib、D-dimer明显升高(P<0.001)。结论:孕妇妊娠前后PT指标无明显变化,不能反映孕妇处于高凝状态,而APTT、Fib、D-dimer可作为反映孕妇机体处于高凝状态的指标,D-dimer升高还说明孕妇有继发性纤溶的发生。

Change of coagulation indexes with women in labor and its clinical significance

Objective：To study the function of coagulation,anti-coagulation and fibrinolysis in later-pregnant women,and to study the clinical value of prothrombin time （ PT）, activated partial thrombopastin time （ AVIT）, fibrinogen （ Fib ） and D-dimer in later-pregnant women. Methods ： Routine coagulation tests PT, APTT, Fib, D-dimer were determined in plasma of 35 later-pregnant women and 40 normal controls. Results ： No significant difference were found in the amounts of PT in two groups （ P 〉 0.05 ） , the amounts of APTT in later-pregnant women were lower than that in normal controls （ P 〈 0.05 ）. The amounts of Fib and D-dimer in later-pregnant women were significantly higher than that in normal controls （ P 〈 0.001 ）. Conclusions ： The PT during pregnancy is not significant changed, PT can＇t indicate the activates coagulation state, however, all APTT, Fib and D-dimer can. D-dimer＇s increase in pregnant women also indicates the occurrence of secondary fibrinolysis.