| PTEN和Survivin在基底细胞癌中的表达 |
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| 引用本文： | 滕蔚,史同新,曲才杰. PTEN和Survivin在基底细胞癌中的表达[J]. 中国麻风皮肤病杂志, 2005, 21(4): 262-264 |
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| 作者姓名： | 滕蔚 史同新 曲才杰 |
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| 作者单位： | 1. 山东省青岛市市立医院皮肤科,266011
2. 青岛大学医学院附属医院皮肤科 |
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| 摘 要： | 目的:探讨抑癌蛋白PTEN和凋亡抑制因子Survivin在基底细胞癌(BCC)中的表达及其意义。方法:采用免疫组化SP法检测20例BCC和30例正常人皮肤中PTEN、Survivin的表达和分布。结果:20例BCC标本中,PTEN表达下调(P<0.05),Survivin表达增高(P<0.001)。PTEN和Survivin的表达无相关性。结论:PTEN异常低表达和Survivin异常高表达可能与BCC的发生、发展有关。
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| 关 键 词： | PTEN 基底细胞癌 Survivin表达 免疫组化SP法 凋亡抑制因子 BCC 抑癌蛋白 表达下调 其意义 表达及 人皮肤 相关性 高表达 低表达 异常 |
Expression of PTEN and Survivin in basal cell carcinoma |
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| TENG Wei,SHI Tong-xin,QU Cai-jie. Expression of PTEN and Survivin in basal cell carcinoma[J]. China Journal of Leprosy and Skin Diseases, 2005, 21(4): 262-264 |
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| Authors: | TENG Wei SHI Tong-xin QU Cai-jie |
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| Affiliation: | TENG Wei,SHI Tong-xin,QU Cai-jie. Department of Dermatology,Qingdao Municipal Hospital,Qingdao,266011 |
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| Abstract: | Objective: To explore the expression of PTEN and an anti-apoptosis factor Survivin and its significance in basal cell carcinoma (BCC). Methods: The expression and distribution of PTEN and Survivin in the skin lesion and normal skin were detected by immunohistochemical technique streptavidin - peroxidase (sp) in 20 cases of BCC and 30 normal controls. Results: The expression of PTEN was down - regulated in BCC ( P < 0.05) . The expression of Survivin was up - regulated ( P < 0.001). The expression of PTEN was not correlated with that of Survivin. Conclusion: The abnormal expression of PTEN and Survivin may contribute to the oncogenesis and development of BCC. |
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| Keywords: | PTEN Survivin basal cell carcinoma immunohistochemistry |
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