单疱病毒性角膜炎大黄素治疗前后补体C3及C反应蛋白的分析

目的：分析中药大黄素对单疱病毒性角膜炎的治疗及免疫调节作用,方法：对62例（86眼）原发感染／复发感染的单疱病毒性角膜炎患者分型,分组,常规用药外施加中药大黄素处理因素进行对照,在二周内观察疗效,时效及补体C3值,C反应蛋白值,结果：原发基质型HSK组的疗效,时效与复发基质型HSK组的时效有统计学意义的改善（团体T检验P＜0．05）,原发基质型及复发浅层型HSK组补体C3值实验前后分别上升1．65g/l和1．41g/l;C反应蛋白值实验前后分别上升5．74mg/l和3．39mg/l（团体T－检验P＜0．05）,结论：中药大黄素对原发基质型,复发浅层型HSK有改善治疗结果,调节补体C3,促进免疫的作用。

Changes in serum complement C3 and C-reactive protein after the treatment on herpes simplex keratitis with Rhubarb

Objective: To analyze the curative and immune opsonic effects of Rhubarb on herpes simplex keratitis (HSK).Methods: 62 patients with newly occurred or recurrent HSK were grouped and treated with Rhubarb, besides of routine treatments, as experimental groups. Complement C3 and C-reactive protein (CRP) were detected before and after 2 weeks of experiment. Results: There was an improvement of the curative effect on primary interstitial HSK (PIHSK). Both in the PIHSK and the recurrent superficial HSK (RSHSK) group, the curative courses became shorter; C3 levels were 1.65g/1 and 1.41g/1 higher than that before the treatments, respectively; and CRP levels were 5.74mg/l and 3.39mg/l higher (T-test, p < 0.05). Conclusions: Rhubarb could improve the curative effects on PIHSK and RSHSK, enhance the modulations of C 3 and the regulations of immuno-reaction.