子宫内膜癌中fhit、survivin的表达及临床意义

目的 :探讨脆性组氨酸三联体基因蛋白fhit和凋亡抑制蛋白survivin在子宫内膜癌中的表达及临床意义。方法 :用免疫组化S P法检测 12例正常子宫内膜 ,15例不典型增生子宫内膜 ,4 2例子宫内膜癌组织中fhit蛋白、survivin蛋白的表达。结果 :fhit蛋白在子宫内膜癌中的阳性率明显低于正常子宫内膜或不典型增生子宫内膜 ,差异有显著性 (P <0 .0 5 )。survivin在正常子宫内膜、不典型增生子宫内膜、子宫内膜癌中的阳性表达率分别为 16 .7%、6 6 .7%、90 .5 % ,差异有显著性 (P <0 .0 5 ) ;在子宫内膜癌组织中 ,随组织学病理分级的增加、手术临床分期的进展、肌层浸润程度的加深和淋巴结的转移 ,fhit蛋白表达阳性率逐渐下降 ,survivin表达强阳性率则逐渐上升 ,差异有显著性 (P <0 .0 5 ) ;fhit蛋白、survivin蛋白表达呈负相关性 (r=- 0 .76 9,P =0 .0 0 0 )。结论 :fhit、survivin在子宫内膜癌的发生、发展过程中起着重要的作用 ,联合检测可为子宫内膜癌的早期诊断、进一步治疗及预后判断提供必要的理论依据。

Expression and significance of fhit,survivin in endometrial adenocarcinoma

Objective:To study the expression and significance of fhit protein,survivin protein in endometrial adenocarcinoma.Method:Immunohistochemical staining S-P method was used to detect the expressio n of fhit protein,survivin in 12 cases normal endometrium,15 cases atypical en dometrium,42 cases endometrial adenocarcinoma.Results:The posit ive expression rate of fhit protein in endometrial adenocarcinoma was lower than that in normal endometrium or atypical endometrium(P<0.05). The expressions rates of survivin in normal en dometrium, atypical endomitrium, endometrial adenocarcinoma were 16.7%, 66.7%, 9 0.5% respectively,and there were statistical significance compare to each other (P<0.05).With the increase of histological grade,surgical stage, muscular invasion,lymphatic metastasis, the expression rate of fhit was decr eased, while the expression of survivin was increased. Negative correlation was also found between fhit and survivin expression(r=-0.769,P=0.000).Conclusion:Fhit and survivin may play im portant roles in oncogenesis and progression of endometrial adenocarcinoma. De tection of fhit, survivin protein may have potential effects on early diagnosis , treatment and prognosis of endometrial adenocarcinoma.