| 高效液相色谱法测定四环素片的含量 |
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| 引用本文： | 严晓明,朱兴保,刘旺培,李志林. 高效液相色谱法测定四环素片的含量[J]. 首都医药, 2012, 0(16): 58-59 |
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| 作者姓名： | 严晓明 朱兴保 刘旺培 李志林 |
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| 作者单位： | [1]广东省韶关市食品药品检验所,512028 [2]广东省韶关市皮肤病医院,512000 |
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| 摘 要： | 目的建立高效液相色谱法测定四环素片含量。方法色谱柱为SUPELCO Discovery C18(250mm×4.6mm,5μm),流动相为0.1%磷酸-甲醇(40:60),检测波长为268nm,柱温为30℃,流速1.0ml/min。结果四环素进样量的线性范围为0.1～8.0μg,r=0.9983(n=7),平均回收率为99.92%,RSD=0.89%(n=6)。结论所用方法准确、灵敏、专属性好,可用于四环素片的质量控制。
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| 关 键 词： | 高效液相色谱法 四环素片 含量测定 |
Content Determination of Tetracycline Tablets by HPLC |
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| Shaoguan Institute for Drug and Food Control,Shaoguan,China,Yan Xiaoming,Zhu Xingbao,Liu Wangpei; Shaoguan City Dermatology Hospital,Shaoguan,China,Li Zhilin. Content Determination of Tetracycline Tablets by HPLC[J]. Capital Medicine, 2012, 0(16): 58-59 |
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| Authors: | Shaoguan Institute for Drug Food Control,Shaoguan,China,Yan Xiaoming,Zhu Xingbao,Liu Wangpei Shaoguan City Dermatology Hospital,Shaoguan,China,Li Zhilin |
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| Affiliation: | Shaoguan Institute for Drug and Food Control, Shaoguan (512028) , China, Yan Xiaoming, Zhu Xingbao, Liu Wangpei; Shaoguan City Dermatology Hospital, Shaoguan (512000) , China, Li Zhilin |
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| Abstract: | Objective was established fo HPLC method the content determination of Tetracycline tablets. Methods The chromatography column was SUPELCO Discovery Cx8 （ ph me wa 250mm×4.6mm, 5μm） , the mobile ase was thanol （ velength 0.1% phosphoric acid- 40 ： 60） , the detection was 268nm, the column temperature was 1.0ml/min. Resul of Tetracycline r=0.9983 （n=7）. 30℃, flow rate was ts The linear range was 0.1-8.0μg with The average recovery was 99.92%, RSB=0.89% （n=6） Oono~usion The method was accurate, sensitive, specific, and can be used for quality control of Tetracycline tablets. |
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| Keywords: | HPLC Tetracycline tablets Content determination |
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