| 锌及络合锌抗银屑病作用的实验研究 |
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| 引用本文： | 付军,崔晞,刘振军,刘娜,丁勃,管益涛. 锌及络合锌抗银屑病作用的实验研究[J]. 山东大学学报(医学版), 2006, 44(12): 1206-1208 |
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| 作者姓名： | 付军 崔晞 刘振军 刘娜 丁勃 管益涛 |
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| 作者单位： | 山东大学公共卫生学院卫生检验教研室,山东,济南,250012;山东省交通医院检验科,山东,济南,250031;山东省药品检验所药理科,山东,济南,250012;潍坊市疾病预防控制中心检验科,山东,潍坊,261041 |
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| 摘 要： | 目的：研究ZnCl2及Zn EDTA对银屑病小鼠模型阴道上皮的有丝分裂作用。方法:使用昆明种雌性小鼠建立小鼠阴道上皮有丝分裂模型。将小鼠模型随机分为阴性对照组、阳性对照组，ZnCl2低、中、高剂量组、Zn EDTA低、中、高剂量组。分别给药10?d。最后1次给药1?h后，腹腔注射秋水仙碱，脱颈椎处死小鼠。光学显微镜下观察细胞有丝分裂。结果:ZnCl2及Zn EDTA的各剂量组均可显著抑制小鼠阴道上皮的有丝分裂（P＜0.05），不同剂量的ZnCl2组间及Zn EDTA组间与阳性对照组间差异无统计学意义。结论:ZnCl2及Zn EDTA对小鼠模型阴道上皮有丝分裂的作用可能与抑制表皮增殖有关。
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| 关 键 词： | 锌 螯合剂 银屑病 上皮细胞 阴道 小鼠 |
| 文章编号： | 1671-7554（2006）12-1206-03 |
| 收稿时间： | 2006-03-21 |
| 修稿时间： | 2006-03-21 |
Effect of Zinc and Zinc-EDTA in inhibiting psoriasis |
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| FU Jun,CUI Xi,LIU Zhen-jun,LIU Na,DING Bo,GUAN Yi-tao. Effect of Zinc and Zinc-EDTA in inhibiting psoriasis[J]. Journal of Shandong University:Health Sciences, 2006, 44(12): 1206-1208 |
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| Authors: | FU Jun CUI Xi LIU Zhen-jun LIU Na DING Bo GUAN Yi-tao |
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| Affiliation: | 1. Department of Chemical and Bacterial Detection, School of Public Health, Shandong University, Jinan 250012, Shandong, China; 2. Department of Clinical Laboratory, Shandong Traffic Hospital, Jinan 250031, Shandong, China; 3. Department of Pharmacy, Shandong Institute of Drug Control, Jinan 250012, Shandong, China; 4. Department of Clinical Laboratory, Weifang Center of Disease Control and Prevention, Weifang 261041, Shandong, China |
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| Abstract: | Objective:To study the effect of Zinc and Zinc-EDTA in inhibiting psoriasis.Methods: Kunming mice of mitotic division model of vaginal epitheliums were randomly divided into eight groups: negative control,positive control,low,middle and high dosage of ZnCl_2,and low,middle and high dosage of Zn-EDTA,and then they were mornitored following ten days consecutive intragastrically administration of saline,Methotrexate,ZnCl_2 and Zn-EDTA.And one hour after last administration,mice were administered colchicines by intraperitoneal injection and sacrificed by taking the cervical vertebrae off.The vaginal mitotic division was observed under light microscope.Results: ZnCl_2 or Zn-EDTA of different dosages could obviously inhibit the mitosis of vaginal epithelial cells(P<0.05).No statistically significant was found between ZnCl_2 or Zn-EDTA and positive control group.Conclusion: ZnCl_2 or Zn-EDTA may inhibit the proliferation of epidermic cells in psoriasis animal model. |
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| Keywords: | ZnCl_2 Chelating Agents Psoriasis Epithelial cells Vaginal Mouse |
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