盐酸达泊西汀治疗早泄的临床研究进展

早泄(PE)是最常见的男性性功能障碍。达泊西汀是一个新型、作用快速的选择性5-羟色胺(5-HT)再摄取抑制剂(SSRIs)。尽管达泊西汀与其他SSRIs有相似的药理作用,但其口服吸收快,半衰期短,排泄快的药动学特征,使其成为适于需时服用治疗PE的药物。临床试验表明,达泊西汀能有效地延长PE患者的阴道内射精的潜伏时间(IELT),改善性功能,且没有严重的不良反应。与传统的SSRIs相比具有更好的安全性和耐受性。本品有可能成为今后改善PE的第一个新药。

Advanced in clinical studies of dapoxetine treatment for premature ejaculation

premature ejaculation(PE) is the most common sexual dysfunction in men.Dapoxetine is a novel,fast-acting selective serotonin(5-HT) reuptake inhibitor.Although dapoxetine has pharmacological similarities to other selective serotonin reuptake inhibitors(SSRIs),its pharmacokinetic properties of rapid-absorbed following oral administration,short half-life and rapid-eliminated make it suitable for on-demand treatment of premature ejaculation(PE).Clinical studies have shown dapoxetine to be effective in prolonging intravaginal ejaculation latency time(IELT),improving sexual function of PE without any major adverse events.It is a safer and more tolerable alternative compared to traditional selective serotonin reuptake inhibitors(SSRIs).