Effects of Continuous Sciatic Nerve Block by Tetrodotoxin on Growth Associated Protein-43 Expression in Dorsal Root Ganglions of Normal and Sciatic Nerve Injury Rats |
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| Authors: | Chen Wang Yong-fa Zhang Xiao-yu Huang |
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| Institution: | Chen Wang(Department of Anesthesia, Second Hospital of Xiamen, Xiamen 361021)；Yong-fa Zhang(Department of Anesthesia, the Second Affiliated Hospital of Shantou University Medical College, Shantou 515041)；Xiao-yu Huang(Department of Anesthesia, the Second Affiliated Hospital of Shantou University Medical College, Shantou 515041)； |
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| Abstract: | Growth associated protein-43 (GAP-43) is considered to be one of the most useful molecular markers for the neural development, nerve regeneration, and neuroplasticity. In most mature neurons, the expression of GAP-43 is at very low or negative level; its expression is triggered in response to the interruption of axonal transport. The purpose of this study was to examine whether continuous sciatic nerve block by tetrodotoxin (TTX) affects GAP-43 expression in the dorsal root ganglion (DRG) of normal and sciatic nerve injury rats. |
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| Keywords: | Rats Nerve Injury Normal Root Expression Associated Growth Tetrodotoxin Nerve Block Continuous normal nerve injury rats dorsal root ganglion purpose study continuous nerve block tetrodotoxin response |
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