Neoclerodane and labdane diterpenoids from Plectranthus ornatus |
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Authors: | Rijo Patrícia Gaspar-Marques Cristina Simões M Fátima Duarte Aida Del Carmen Apreda-Rojas María Cano Félix H Rodríguez Benjamín |
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Affiliation: | Faculdade de Farmácia da Universidade de Lisboa, Centro de Estudos de Ciências Farmacêuticas (CECF), Av. das For?as Armadas, P-1649-019 Lisboa, Portugal. |
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Abstract: | Three new diterpenoids, a neoclerodane and two labdane derivatives, have been isolated from an acetone extract of Plectranthus ornatus. The structures of these compounds (plectrornatins A-C, 1-3, respectively) were established mainly by spectroscopic means, particularly by 1D and 2D NMR studies and, in the case of the neoclerodane 1, by an X-ray diffraction analysis. Compounds 1 and 3 showed moderate antimicrobial activity against five Candida species and selected Gram negative and Gram positive bacteria strains. |
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