乳腺浸润性导管癌钼靶X线表现与C-erbB-2的关系

目的:探讨浸润性导管癌钼靶X线表现和C-erbB-2间的关系,评价依据导管癌钼靶X线,术前预测C-erbB-2的表达的可行性。方法:乳腺钼靶和病理证实的浸润性导管癌60例,术后大体标本经免疫组织化学染色判断C-erbB-2的表达情况。把浸润性导管癌钼靶X线表现中的恶性钙化、肿块边缘的毛刺与C-erbB-2的表达情况进行对比。结果:导管癌60例中,肿块伴毛刺者25例,有钙化者28例;C-erbB-2表达阳性33例,钙化组C-erbB-2的阳性率与无钙化组相比有高度统计学意义(P<0.05)。无毛刺组C-erbB-2的阳性率较毛刺组略高,但无统计学意义。结论:IDC中钙化性肿块和C-erbB-2有相关性,钼靶X线征像可反映C-erbB-2的表达情况。

Relationship between mammographic featuers and C-erbB-2 in infiltrating ductal carcinoma of breast

Objective:To probe the relationship between the appearance on mammography and C-erbB-2 in infiltrating ductal carcinoma of breast(IDC) and evaluate the possibility of predicting the expression of C-erbB-2 in IDC preoperation by means of mammography.Methods:60 patients with IDC confirmed pathologically were involved in this study,and the specimen was examined immuhistochemistically to judge the expression of C-erbB-2.The malignant calcifications and marginalspeculation around tumors on Mo-target X-ray images were compared with the expression of C-erbB-2.Results:Spicule signs were seen in 25 of the 60 cases,and calcifications,in28;C-erbB-2 positve erpression was found in 33.Significant difference in C-erbB-2 positive rate existed between the lesion with calcifications and the lesion without calcifications(P<0.05).C-erbB-2 positive rate in lesions without spicule sign was higher than that in lesions with spicule sign,but there was no statistical difference.Conclusion:A certain correlation exists between calcification and CerbB-2 expression in patients with IDC.The appearance of infiltrating ductal carcioma(IDC) on Mo-target X-ray images may be used to predict the expression of CerbB-2 in IDC.