大鼠烧伤早期各内脏内皮素的变化

探讨烧伤后内皮素变化及其在骨脏损害中的应用。方法采用大鼠３０％Ⅲ度烧伤模型动态观察大鼠烧伤后血浆，心，肝，肺，肾脏内皮素的变化规律及应用非选择造反性内皮素受体拮抗剂ＰＤ１４５０６５对烧伤大鼠内脏损害的作用。

The dynamic changes and significances of endothelins in early burned rats]

OBJECTIVE: To elucidate the significance of endothelins in visceral injury at the early stage of burn. METHODS: By use of a 30% (III degree) total body surface area (TBSA) burn rat model, we measured the concentration of endothelins in plasma, heart, liver, lung, kidney, and observed the effects of PD145065, a kind of non-selective ETA-ETB receptor antagonist, on visceral impairment. RESULTS: Not only did the endothelin concentration in plasma of burnt rat elevated significantly, showing a peak at 6 hours postburn, but also the endothelin contents in internal organs apparently increased. The changes in endothelin in liver or kidney were negatively correlated with the alteration in renal or hepatic blood flow. Moreover, administration of endothelin receptor antagonist PD145065, without affecting the arterial blood pressure, could revert the decrease of renal or hepatic blood flow to some extent, reduce the water contents of heart, liver, lung, kidney postburn. CONCLUSION: The abnormal changes in endothelins postburn contribute to visceral injury in the early postburn stage in rats.