补锌对烫伤大鼠锌,生长激素及羟脯氨酸的影响

目的 探讨补锌对创面愈合的影响。方法 ＳＤ大鼠８０只，随机分成伤前对照组，正常饲料组（Ｎ组），创面补锌组（Ｗ组），口服补锌组（Ｈ组），后三组动物致烫伤，各组分别于伤后１，３，７天活杀８只大鼠，留取血清，烫伤皮肤，观察不同途径补锌对烫伤和血清锌、生长激素、皮肤锌、羟脯氨酸的影响。结果 Ｎ、Ｗ组血清、皮肤锌伤后第１天下降，而Ｈ组明显上升，分别为Ｎ组的２，４，２．０倍（Ｐ〈０．０１），Ｗ组伤后３，７天皮

Effects of supplement Zn on levels of Zn in serum, growth hormone and hydroxyproline]

OBJECTIVE: In order to research the effects of supplement Zn on wound healing, the changes of Zn in serum and skin, growth hormone and hydroxyproline of skin were observed in burn rats. METHOD: 80 SD rats were randomly divided into four groups: Control group of 8 rats, N group (diet containing Zn 40 micrograms/g), W group (application of Zn on burn skin), H group (diet containing Zn 80 micrograms/g). 8 rats of each group were killed on 1, 3, 7 days after burn. RESULTS: The levels of serum Zn declined on 1 day postburn in N and W groups, whereas the content of serum Zn in H group elevated and were 2.4, 2.0 times as much as that of N and W groups respectively (P < 0.01). Zn in burn skin increased significantly on 3, 7 days in W group and was 1.3, 1.5 times as much as that of N group. Serum growth hormone increased in all groups postburn. The highest level appeared in H group. Hydroxyproline in burn skin decreased in all groups, but it began to increase on 7 day postburn in W group. CONCLUSION: Supplementation of Zn by diet rapidly raises the levels of Zn in serum, burn skin and growth hormone. It is beneficial to apply Zn to the wound to improve wound healing. Hydroxyproline increased significantly with application of Zn to burn wound. It is better to supply Zn by diet and topical application simultaneously.