Technical and clinical feasibility of contrast-enhanced ultrasound evaluation of long bone non-infected nonunion healing |
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| Authors: | Simona Pozza Armanda De Marchi Chiara Albertin Domenico Albano Ginevra Biino Domenico Aloj Luca Maria Sconfienza |
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| Affiliation: | 1.Department of Imaging,Azienda Ospedaliera Universitaria Città della Salute e della Scienza, CTO Hospital,Turin,Italy;2.Department of Imaging,Ospedale Humanitas Gradenigo,Turin,Italy;3.Department of Radiology,Di.Bi.Med., University of Palermo,Palermo,Italy;4.Institute of Molecular Genetics,National Research Council of Italy,Pavia,Italy;5.Department of Orthopedics and Traumatology,Sant’Andrea Hospital,Vercelli,Italy;6.Unit of Diagnostic and Interventional Radiology,IRCCS Istituto Ortopedico Galeazzi,Milan,Italy;7.Department of Biomedical Sciences for Health,University of Milano,Milan,Italy |
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| Abstract: | PurposeTo assess the technical feasibility of contrast-enhanced ultrasound (CEUS) in the monitoring of non-infected long bone nonunion healing.MethodsTwenty-five patients (16 males; mean age: 40.4?±?11.7) with long bone nonunion were treated using surgery and mesenchymal stem cells and platelet-rich plasma. They performed CEUS up to 15 days before, 7 days, 4 and 8 weeks after treatment. To categorize the angiogenesis around the fracture site, the microvascular blood flow from CEUS was classified into four categories, depending on the portion of the investigated area that was involved in the neovascularization process: grade 0?=?0%; grade 1?=?0–30%; grade 2?=?30–70%; grade 3?=?70–100%. Nonparametric Friedman and Wilcoxon statistics were used.ResultsBefore treatment, neovascularization was graded as 0 in 15/25 patients, as 1 in 10/25. Vascularity significantly increased over time ( P?ConclusionCEUS is a feasible method to monitor healing in patients with long bone nonunion. |
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