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Analysis of three ultrasound elastography techniques for grading liver fibrosis in patients with chronic hepatitis B
Authors:Xinping Ren  Shujun Xia  Zhongxin Ni  Weiwei Zhan  Jianqiao Zhou
Affiliation:1.Ultrasonic Department, Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai,China
Abstract:

Background

Evaluation of liver fibrosis is important to assess prognosis and guide the treatment for chronic hepatitis B.

Objective

To analyze and compare transient, point, and two-dimensional (2D) shear wave elastography techniques in grading the liver fibrosis.

Methods

Based on the severity of liver inflammation and fibrosis (Scheuer criteria), 158 patients with chronic hepatitis B were assigned into group 1 (either G or S classification?

Results

A total of 158 patients were enrolled into the study, with 39.2% (62) female and mean age of 42.8 (standard deviation 19.1) years old. Transient elastography could not differentiate between group 1 and group 2 patients (P?=?0.12), whereas point and 2D elastography examinations could distinguish patients in group 1 from group 2 (P?

Conclusion

Point and 2D elastography were superior to transient elastography to detect liver fibrosis and guide clinical anti-viral treatment. Analysis of combined transient, point, and 2D elastography techniques showed the better diagnostic accuracy for liver fibrosis.
Keywords:
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