Role of vascular endothelial growth factor in adult hippocampal neurogenesis: implications for the pathophysiology and treatment of depression |
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Authors: | Fournier Neil M Duman Ronald S |
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Affiliation: | Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, United States |
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Abstract: | It is now well established that the adult brain has the capacity to generate new neurons throughout life. Although the functional significance of adult neurogenesis still remains to be established, increasing evidence has implicated compromised hippocampal neurogenesis as a possible contributor in the development of major depressive disorder. Antidepressants increase hippocampal neurogenesis and there is evidence in rodent models that the therapeutic efficacy of these agents is attributable, in part, to this neurogenic effect. As such, considerable interest has been directed at identifying molecular signals, including neurotrophic factors and related signaling pathways that are associated with antidepressant action and could operate as key modulators in the regulation of neurogenesis in the adult hippocampus. One interesting candidate is vascular endothelial growth factor (VEGF), which is known to possess strong neurogenic effects. In this review, we will discuss the involvement of VEGF signaling in the etiology and treatment of depression. |
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Keywords: | ANP, transient amplifying neuronal progenitor cell BDNF, brain-derived neurotrophic factor BrdU, bromodeoxyuridine ECS, electroconvulsive seizure FGF-2, fibroblast growth factor IGF-1, insulin-like growth factor MDD, major depressive disorder NSF, novelty suppressed feeding QNP, quiescent neuronal precursor cell SGZ, subgranular zone SVZ, subventricular zone VEGF, vascular endothelial growth factor |
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