| 胰岛素样生长因子—I及胰岛素样生长因子结合蛋白—3与 … |
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| 作者姓名： | Qian M Fan Q Bian X Zhu L Lang J |
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| 作者单位： | 中国医学科学院中国协和医科大学协和医院妇产科,北京 |
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| 摘 要： | 目的 检测孕妇静脉血、脐血中胰岛素样生长因子－Ｉ（ＩＧＦ－Ｉ）及胰岛素样生长因子结合蛋白－３（ＩＧＦＢＰ－３）水平,探讨ＩＧＦ－Ｉ、ＩＧＦＢＰ－３与胎儿宫内发育的关系。方法 采用美国ＤＳＬ公司试剂盒。总计８１例孕妇,其中正常孕妇３８例,妊娠糖尿病孕妇２０例,正常妊娠分娩巨大儿孕妇２３例,采用放射免疫方法测定。结果 正常组及巨大儿组孕妇静脉血ＩＧＦ－Ｉ与新生儿体重呈正相关（ｒ＝０．６５３,ｒ＝０．６
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| 关 键 词： | IGF－I 胎儿宫内发育 IGFBP－3 |
Insulin-like growth factor-I(IGF-I), and its binding protein-3 (IGFBP-3) correlated with fetal development |
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| Qian M,Fan Q,Bian X,Zhu L,Lang J.Insulin-like growth factor-I(IGF-I), and its binding protein-3 (IGFBP-3) correlated with fetal development[J].Acta Academiae Medicinae Sinicae,2000,22(5):476-478. |
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| Authors: | Qian M Fan Q Bian X Zhu L Lang J |
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| Institution: | Department of Gynecology and Obstetrics, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. |
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| Abstract: | OBJECTIVE: To study the relations between IGF-I, IGFBP-3 and human fetal growth. METHODS: The blood samples of maternal serum (MS) and umbilical cord serum (UCS) from 81 cases with singleton term pregnancy including 38 cases of normal pregnancy (NP), 20 cases of gestational diabetic mellitus (GDM), 23 cases of macrosomia of non-diabetic pregnancy (MNDP) were examined for IGF-I and IGFBP-3 levels by immunoassay kit from DSL, USA. RESULTS: IGF-I in MS of NP and MNDP showed a positive correlation with birth weight (BW) (r = 0.653 and r = 0.640 respectively, both P < 0.01). IGF-I of MS in MNDP was higher than that in NP (P < 0.05). IGF-I of MS and UCS in GDM were higher than that in NP (P < 0.05). IGF-I and IGFBP-3 of UCS in these three groups were significantly lower than that of MS (P < 0.001). CONCLUSION: Detection of IGF-I in MS can assess fetal intra-uterus growth, birth weight and has certain value of predicting macrosomia. IGF-I and IGFBP-3 play important roles for human fetal growth. |
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