| 抗菌肽的抗肿瘤研究进展 |
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| 引用本文： | 李正洋,童 玥,姚文兵.抗菌肽的抗肿瘤研究进展[J].药学与临床研究,2010,18(4):377-380. |
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| 作者姓名： | 李正洋 童 玥 姚文兵 |
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| 作者单位： | 中国药科大学生命科学与技术学院,南京,210009 |
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| 摘 要： | 抗菌肽（AMPs）是具有抗菌活性的一类多肽,广泛存在于生物界。抗菌肽对肿瘤细胞有广谱杀伤作用,却对正常的哺乳动物细胞没有毒性作用。本文概述抗菌肽杀伤肿瘤细胞的多种作用机制,并探讨了将其开发为新型抗肿瘤药物的可行性。
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| 关 键 词： | 抗菌肽 抗肿瘤活性 作用机制 应用前景 |
| 收稿时间： | 2010/5/12 0:00:00 |
| 修稿时间： | 2010/6/3 0:00:00 |
Evolution of Anticancer Mechanism of Antimicrobial Peptides |
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| LI Zheng-yang,TONG Yue and YAO Wen-bing.Evolution of Anticancer Mechanism of Antimicrobial Peptides[J].Pharmacertical and Clinical Research,2010,18(4):377-380. |
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| Authors: | LI Zheng-yang TONG Yue and YAO Wen-bing |
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| Institution: | School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China;School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China;School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Antimicrobial peptides (AMPs), which have been separated from a great number of organisms, are novel antibacterial agents. Many studies have demonstrated that, some AMPs exhibit a broad spectrum of cytotoxic activity against tumor cells, but not to normal mammal cells. This review focuses on recent studies about anticancer mechanism of AMPs, and the application prospect of AMPs as anticancer drugs. |
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| Keywords: | Antimicrobial peptides Anti-cancer activity Mechanism Application prospect |
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