抗焦虑治疗对急性冠脉综合征QT离散度的影响

目的　观察急性冠脉综合征患者中有焦虑障碍者经抗焦虑治疗后QT离散度变化。方法　 5 8例确诊急性冠脉综合征患者经焦虑自评量表测评 ,按标准分大于 5 1分者为焦虑障碍。并对 42例焦虑障碍患者随机分为抗焦虑组和非抗焦虑组两组。基础治疗相同 ,抗焦虑组用黛力新 10 .5mg早晨、中午各 1次。分别在治疗前及治疗后第 2周、第 4周测量QT离散度和校正QT离散度 ,并进行治疗前后两组间比较。结果　 5 8例急性冠脉综合征中有焦虑障碍者 42例 ,占 72 %。抗焦虑组和非抗焦虑组两组 ,治疗前QT离散度及校正QT离散度差异无显著性 (P >0 .0 5 ) ,治疗后第 2周抗焦虑组QT离散度和校正QT离散度即有减少 ,与治疗前及非抗焦虑组比差异均有显著性 (P <0 .0 1) ,而非抗焦虑组治疗后第 4周与治疗前比差异无显著性 (P >0 .0 5 )。结论　急性冠脉综合征患者中大多合并有焦虑障碍 ,焦虑患者与QT离散度值增大有着密切相关性 ,抗焦虑治疗能使QT离散度减少 ,从而降低心脏不良事件发生率 ,提高患者生活质量。

Effects of QT dispersion variation in acute coronary syndrome with antianxiety treatment

Objective To observe the QT dispersion variation of the anxiety-patients with antianxiety treatment in the acute coronary syndrome.Methods 58 people with acute coronary syndrome exactly were assessed by self-evalution chart. The patients over 51' were anxiety. 42 patients with anxiety were divided into antianxiety group and non-antianxiety group in random. The basic treatment was identical. The antianxiety group was given Deanxit(10.5 mg Bid). QTd and rectified QTd were measured before treatment, and after the second week, the forth week with treatment. The group before treatment was compared with that after treatment. Results There is 42 patients with anxiety among 58 people with acute coronary syndrome(72%). There is no significant difference QTd and corrected QTd between the antianxiety group and no non-antianxiety group before treatment(P>0.05). QTd and corrected QTd drop off after antianxiety treatment for two weeks. There is remarkable difference between the patients with antianxiety treatment for two weeks and the ones before treatment, and the non-antianxiety group(P<0.01).There is no striking difference between the patients before treatment and the non-antianxiety group after four weeks(P>0.05). Conclusions In the patients with acute coronary syndrome, there is significant correlation between the anxiety people and the increase of QTd. The anti-anxiety treatment can reduce QTd, which can cut down the incidence of cardiac accident. So patient's life quality are improved.