| 国产相对低分子质量肝素在血液透析中的抗凝疗效 |
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| 引用本文： | 罗惠民,张金黎,马宝栋,马玉林,杨燕,陈慧,李明. 国产相对低分子质量肝素在血液透析中的抗凝疗效[J]. 中国临床药学杂志, 2000, 9(2): 67-69 |
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| 作者姓名： | 罗惠民 张金黎 马宝栋 马玉林 杨燕 陈慧 李明 |
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| 作者单位： | 1. 云南省第一人民医院肾内科 昆明 650032
2. 云南省第一人民医院检验科 昆明 650032 |
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| 摘 要： | 目的：观察应用国产相对低分子质量肝素（ＬＭＷＨ）在血液透析中的抗凝疗交瑟速避凝、肝素钙进行比较。方法：５例长期维持性血液透析患者能者在对照，按顺序分别给予国产ＬＭＷＨ、速避凝、肝下各６次作为血液透析抗凝剂，观察的器血凝血，穿刺点压迫止血时间，透析器对血肌酐、尿素氮清除率，监测白部分凝血活酶时间（ＫＰＴＴ）、凝血酶时间（ＴＴ）及血常规变化。结果：国产ＬＭＷＨ、速避凝对ＫＰＴＴ～ＴＴ影响不明显，而肝素
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| 关 键 词： | 相对低分子质量肝素 血液透析 抗凝疗效 |
| 文章编号： | 1007-4406(2000)02-0067-03 |
Effect of homemade low molecular weight heparin on hemodialysis |
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| Luo Huimin,Zhang Jinli,Ma Baodong,. Effect of homemade low molecular weight heparin on hemodialysis[J]. Chinese Journal of Clinical Pharmacy, 2000, 9(2): 67-69 |
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| Authors: | Luo Huimin Zhang Jinli Ma Baodong |
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| Abstract: | AIM: To study the anticoagulant effectiveness of low molecular weight heparin (LMWH) in hemodialysis and to compare with fraxiparine or heparin calcium. METHODS: LMWH, fraxiparine or heparin calcium were given respectively in 5 patients on maintenance hemodialysis for 6 consecutive times. Coagulation in dialyzer , urea and creatinine clearance of dialyzer, hemostatic time of point of puncture and changes in kaolin partial thromboplastin time (KPTT) and thrombin time (TT) were observed. RESULTS: KPTT and TT were significantly shorter during LMWH or fraxiparine than that of heparin calcuim. There were no differences of coagulation in dialyzer, effective urea and creatinine of clearances of dialyzer. CONCLUSION: The anticoagulative efficiency is similar between LMWH and fraxiparine. |
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| Keywords: | low molecular weight heparin hemodialysis efficiency |
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