Modulation by S-adenosyl-methionine and S-adenosyl-homocysteine of the human leucocytes histamine release |
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| Authors: | Y. PACHECO,O. MACOVSCHI&dagger ,N. BIOT,P. FONLUPT&dagger ,M. PERRIN-FAYOLLE,H. PACHECO&dagger |
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| Affiliation: | Clinic of Pneumology, Lyon-sud Hospital Centre, Sainte-Eugéinie, 69230 Saint-Gems-Laval, France;Department of Biological Chemistry, I.N.S.A. of Lyon, 69100 Villeurbanne, France |
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| Abstract: | Methylation of membrane phospholipids is an important stage in the process of histamine release. This methylation reaction can be modulated by S-adenosyl-methionine (SAM) as well as by S-adenosyl-homocysteine (SAH). The influence of SAM and of SAH upon the histamine release of leucocytes from asthmatic and normal subjects were compared. In concentration of 10-4M, SAM enhanced spontaneous and the specifically induced histamine release. In concentration of 10-5 M SAM enhanced the histamine release only in normals. This phenomenon could indicate a deficit in methyl-transferase activity in the asthamatics. In concentration of 10-4 M, SAH reduced spontaneous and specifically induced histamine release, having an effect comparable to that of 10-4 M Theophylline. |
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