头孢丙烯分散片在Beagle犬体内的药动学和相对生物利用度研究

目的建立高效液相色谱（HPLC）法测定犬血浆中头孢丙烯的质量浓度,研究头孢丙烯分散片在Beagle犬体内的药动学和相对生物利用度。方法 12只Beagle犬双周期随机交叉单剂量口服500mg头孢丙烯分散片和普通片剂,洗净期为1周,采用HPLC法测定血浆中头孢丙烯的质量浓度。结果分散片与普通片的体内过程基本一致,其主要药代动力学参数峰浓度（Cmax）分别为（48.7±4.2）μg/mL和（51.1±3.3）μg/mL,达峰时间（Tmax）分别为（1.5±0.3）h和（2.0±0.4）h,半衰期（t1/2）分别为（1.2±0.3）h和（1.6±0.4）h,0～24h药-时曲线下面积（AUC0-24）分别为（188.9±27.5）μg/（h·mL）和（208.2±34.3）μg/（h·mL）。结论头孢丙烯分散片口服后吸收迅速,平均相对生物利用度为90.7%。

Study on in Vivo Pharmacokinetics and Relative Bioavailability of Cefprozil Dispersible Tablet in Beagle Dogs

Objective To establish an HPLC method for the determination of cefprozil serum concentration and to study the in vivo pharmacokinetics and the relative bioavailability of Cefprozil Dispersible Tablet in Beagle dogs.Methods 12 Beagle dogs received the single oral dose of cefprozil 500 mg in dispersible tablets or common tablets with doublecycle randomized cross-over.The clearing period was 1 week. The cefprozil concentration was detected by HPLC.Results The intracorporal process of dispersible tablets was basically consistent with that of the common tablets.The main pharmacokinetic parameters were as follows：Cmax was （48.7±4.2）μg/mL and （51.1±3.3）μg/mL,Tmax was （1.5±0.3）h and （2.0±0.4）h,t1/2 was （1.2±0.3）h and （1.6±0.4）h,AUC0-24 was （188.9±27.5）μg/（h·mL） and （208.2±34.3）μg/（h·mL）.Conclusion Cefprozil Dispersible Tablet is rapidly absorbed after oral administration with the average relative bioavailability of 90.7%.