Volumetric bone mineral density and bone size in sleep-deprived individuals |
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Authors: | B L Specker T Binkley M Vukovich T Beare |
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Institution: | (1) EA Martin Program in Human Nutrition, EAM Bldg South Dakota State University, 1100 Rotunda Lane North, P.O. Box 2204, Brookings, SD 57007, USA;(2) Exercise Physiology Laboratory, South Dakota State University, Brookings, SD 57007, USA |
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Abstract: | Introduction Chronic sleep deprivation, which is associated with several age-related pathologies and altered endocrine function, may adversely
affect bone. Our a priori hypothesis was that bone mineral density was lower in sleep-deprived (<6.5 h/night) vs. sleep-adequate
(>6.5-10 h/night) individuals.
Methods Cross-sectional analysis of sleep and bone data on 1,146 individuals (652 women) was performed. Measurements were obtained
at the distal radius by pQCT, and the spine and hip by DXA. Bone differences between sleep-deprived and sleep-adequate groups
were compared after stratifying by sex and controlling for covariates.
Results Overall, 19% of the population was sleep deprived. Sleep-deprived women had lower cortical volumetric BMD (1,208±4 vs. 1,219±2 mg/cm3, P=0.03) than sleep-adequate women. Sleep-deprived men had lower pSSI, an estimate of torsional bending strength, than sleep-adequate
men (358±10 vs. 382±5 mm3, P=0.04), due to a slightly smaller periosteal circumference (43.9±0.4 vs. 44.8±0.2 mm, P=0.07) and cortical area (103±2 vs. 106±1±mm2, P=0.06).
Conclusion Sleep deprivation is associated with some, but not all, bone outcomes. These findings may have important public health significance
given the increasing prevalence of sleep deprivation. |
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Keywords: | Aging Body composition Bone density Bone size Sleep |
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