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TACE与125I放射性粒子植入序贯治疗HCC的临床研究
引用本文:张云峰,曹贵文,崔新江,宁厚法,杨莉莉. TACE与125I放射性粒子植入序贯治疗HCC的临床研究[J]. 医学影像学杂志, 2010, 20(9): 1377-1380
作者姓名:张云峰  曹贵文  崔新江  宁厚法  杨莉莉
作者单位:潍坊医学院附属医院影像中心,山东,潍坊,261041
摘    要:目的:探讨经导管肝动脉化疗栓塞(TACE)与125I放射性粒子植入术序贯治疗肝细胞肝癌(hepatic carcinoma,HCC)的可行性和临床治疗效果。方法:回顾性研究确诊为HCC的患者86例,A组54例(单纯TACE组),B组32例(TACE与125I放射性粒子植入术序贯治疗组),通过对比观察患者肝功能、AFP、肿瘤大小变化、生存时间,分析TACE与125I放射性粒子植入术序贯治疗HCC的疗效。结果:术后3月A、B两组总体有效率(CR+PR)分别为24.1%(13/54)、59.3%(19/32),差异有显著性(P〈0.05);术后1月A、B两组AFP下降差异有显著性(P〈0.05);术后6月、12月、36月生存率B组为90.6%(29/32)、81.3%(26/32)、43.8%(14/32),明显高于A组的48.1%(26/54)、33.3%(18/54)、18.5%(10/54)(P〈0.05)。结论:TACE与125I放射性粒子植入术序贯治疗HCC能达到较理想的治疗效果,是一种安全有效的方法。

关 键 词:肝细胞性肝癌  125I放射性粒子  经导管肝动脉化疗栓塞  序贯治疗

Clinical study on sequential therapy of TACE combined with 125I radioactive particles implantation in hepatic carcinoma
ZHANG Yun-feng,CAO Gui-wen,CUI Xin-jiang,NING Hou-fa,YANG Li-li. Clinical study on sequential therapy of TACE combined with 125I radioactive particles implantation in hepatic carcinoma[J]. Journal of Medical Imaging, 2010, 20(9): 1377-1380
Authors:ZHANG Yun-feng  CAO Gui-wen  CUI Xin-jiang  NING Hou-fa  YANG Li-li
Affiliation:Medical Imaging Center,the Affiliated Hospital of Weifang Medical College,Weifang 261041,P.R.China
Abstract:Objective:To evaluate the feasibility and the clinic efficacy of sequential therapy of TACE combined with 125I radioactive particle implantation in hepatic carcinoma. Methods:86 cases of hepatic carcinoma were retrospectively collected and divided into two groups:54 patients in group A (TACE alone) 32 patients in group B (TACE combined with 125I radioactive particles implantation sequential therapy). Hepatic function,AFP,the tumor volume and live time of 86 cases of the hepatic carcinoma were analyzed trpectively. Results:The overall response (CR+PR) of group A and group B were 24.1%(13/54) and 59.3%(19/32) respectively 3 months after operation. There was a significant difference between them (P0.05). AFP was decreased 1 month after operation in two groups,and the difference between them was significant. Survival rates of 6,12 and 36 months in group B(90.6%,81.3% and 43.8%) were higher than those in group A(48.1%,33.3% and 18.5%)(P0.05).Conclusion:Sequential therapy of TACE combined with 125I radioactive particle implantation in treating hepatic carcinoma can get better therapeutic efficacy than TACE alone. It's a safe and effective method.
Keywords:Hepatic carcinoma  125I radioactive particles  Transcatheter arterial chemoembolization  Sequential therapy
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