急性冠状动脉综合症患者超敏C反应蛋白和血脂检测及临床意义

目的:探讨血清超敏C反应蛋白(hs-CRP)和非高密度脂蛋白胆固醇(NHDL-C)在急性冠状动脉综合症(ACS)的临床价值。方法:用Roche/MODULAR P生化分析仪胶乳增强免疫比浊法检测hs-CRP、酶法检测总胆固醇(TC)、甘油三酯(TG)、直接匀相法检测高密度脂蛋白胆固醇(HDL-C),非高密度脂蛋白胆固醇(NHDL-C)计算法(TC-HDL-C)。结果:ACS组血清hs-CRP为(13.40±7.80)mg/L、TC(4.84±1.02)mmol/L、TG(1.57±0.86)mmol/L、HDL-C(1.06±0.31)mmol/L、NHDL-C(3.58±0.92)mmol/L;健康对照组血清hs-CRP为(0.82±0.74)mg/L、TC(4.68±0.81)mmol/L、TG(1.38±0.77)mmol/L、HDL-C(1.42较,hs-CRP、HDL-C、NHDL-C水平差异均有显著性(P<0.01),TC、TG水平差异均无显著性;ACS组hs-CRP水平分别与HDL-C、NHDL-C水平进行相关分析,均无直线相关性(r=0.125,0.134);健康对照组用同样指标进行相关分析,也均无直线相关性(r=0.106,0.113)。结论:血清hs-CRP、HDL-C、NHDL-C水平与ACS事件发生有关,可作为ACS患者诊断、治疗、预后的观察指标。

Detection of High Sensitivity C-Reactive Protein and Lipids with Acute Coronary Syndome and Its Clinical Application

Objective To investigate the clinical value of serum high-sensitivity C-Reactive Protein(hs-CRP) and non-high-density liporotein cholesterol(NHDL-C) on patients with the acute coronary syndrome(ACS).Methods Serum hs-CRP is measured through partical enhanced immuoturbidimetric method by analysis instrument Roche / MODULAR P;Serum total cholesterol(TC) and triglycerides(TG) is examined by enzyme method;Serum high-density lipoprotein cholesterol(HDLC) is detected by the homogenous method;Serum non-high-density lipoprotein cholesterol(NHDL-C) is expressed by the remainder of TC decreased HDL-C(TC-HDL-C).Results The group of ACS: The density of serum hs-CRP is(13.40±7.80)mg/L.TC is(4.84±1.02)mmol/L.TG is(1.57±0.86)mmol/L.HDL-C is(1.06±0.31)mmol/L and NHDL-C is(3.58±0.92)mmol/L;For healthy control group:The density of serum hs-CRP is(0.82±0.74)mg/L、TC is(4.68±0.81)mmol/L,TG is(1.38±0.77)mmol/L、 HDL-C is(1.42±0.37)mmol/L and NHDL-C is(3.07±0.61)mmol/L.There was significant difference in the serum level of hs-CRP、 HDL-C and NHDL-C between the ACS group and the control group(P<0.01);The serum level of TC and TG had no significant difference between the two groups.It was not remarkable positive related in the serum density of hs-CRP between HDL-C and NHDL-C in group of ACS,respectively.related coefficient(r=0.125,0.134);It was also demonstrated that there was no significant related in the serum density of hs-CRP between HDL-C and NHDL-C in healthy control group,respectively.related coefficient(r= 0.106,0.113).Conclusion It was found that a close correlation of the level of serum hs_CRP、HDL-C and NHDL-C with the rate of the ACS events,and it was regarded as an in dicator for the diagnosis.treatment and prognosis of the acute coronary syndrome.