| 珍菊降压片联合氨氯地平片对肾性高血压大鼠血压和内皮功能的影响 |
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| 引用本文： | 尹广利,冯子南,王植荣,王庆凯. 珍菊降压片联合氨氯地平片对肾性高血压大鼠血压和内皮功能的影响[J]. 中国医药导刊, 2012, 0(2): 286-287 |
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| 作者姓名： | 尹广利 冯子南 王植荣 王庆凯 |
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| 作者单位： | 河北省沧州中西医结合医院心内一科 |
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| 基金项目： | 沧州市科技局立项课题(编号:08ZD247) |
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| 摘 要： | 目的:探讨珍菊降压片联合氨氯地平片对肾性高血压大鼠(RHR)血压和血浆内皮素(ET-1)、一氧化氮(NO)的影响。方法:建立两肾一夹肾性高血压大鼠模型,给予肾性高血压大鼠灌服珍菊降压片及氨氯地平片4周,尾袖法测量大鼠尾动脉收缩压,应用放射免疫法及硝酸还原酶法检测肾性高血压大鼠ET-1、NO水平。结果:珍菊降压片联合氨氯地平片降压效果良好,且能明显升高肾性高血压大鼠NO水平及降低ET-1。结论:珍菊降压片联合氨氯地平片较单用氨氯地平片可以明显升高NO水平及降低ET-1,更好的控制肾性高血压大鼠血压。
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| 关 键 词： | 高血压 内皮素 一氧化氮 珍菊降压片 氨氯地平片 |
Effects of Zhenjvjiangya Tablet Combined with Amlodipine Tablet on Blood Pressure and Endothelial Function in Renal Hypertensive Rats |
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| Affiliation: | Yin Guang-li,Feng Zin-an,Wang Zhi-rong,et al.(Hebei Provincial Hospital of Integrative Chinese and Western Medicine,Cangzhou 061001,China) |
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| Abstract: | Objective:To study Zhenjvjiangya tablet combined with Amlodipine tablet on blood pressure and endothelial function in renal hypertensive rat(RHR).Methods:The two-kidney and one-clip rat method was established.The tail artery blood pressure and plasma endothelin,nitric oxide level were measured after administration with Zhenjvjiangya tablet and Amlodipine tablet.Results:Effect of Zhenjvjiangya tablet combined with Amlodipine tablet on blood pressure is remarkable,and can increase the nitri coxide level and decrease endothelin.Conclusion:Zhenjvjiangya tablet combined with Amlodipine tablet can obviously reduce the blood pressure,increas the nitric oxide level and decrease endothelin. |
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| Keywords: | Hypertension Endothelin-1 Nitric oxide ZhenjuJiangyaTablet Amlodipine tablet |
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