| 输注离体照射骨髓基质祖细胞对造血辐射损伤恢复的影响 |
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| 引用本文： | 刘及,刘光金,凌翎. 输注离体照射骨髓基质祖细胞对造血辐射损伤恢复的影响[J]. 吉林大学学报(医学版), 1988, 0(6) |
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| 作者姓名： | 刘及 刘光金 凌翎 |
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| 作者单位： | 白求恩医科大学环境病理教研室(刘及，刘光金)，白求恩医科大学环境病理教研室(凌翎) |
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| 摘 要： | 本文观察了混输不同剂量离体照射的骨髓基质祖对细胞受致死剂量照射小鼠造血重建的作用。给果发现,混输离体照射强化基质细胞者在骨髓细胞数、CFU—S含量和幼粒细胞分类等指标上,均较单输注骨髓细胞或未照射基质细胞者明显提高。最佳照射剂量为10Gy。并结合以前本室工作讨论了其作用机理。
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| 关 键 词： | 体外照射 造血基质细胞 混输基质细胞 造血再建 骨髓细胞 小鼠 |
Effect of cotransplantation of BMC and irradiated BMSPC in various doses on hemopoietic reconstitution in mice lethally irradiated |
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| Liu Ji,Liu Guangjin and Ling Ling. Effect of cotransplantation of BMC and irradiated BMSPC in various doses on hemopoietic reconstitution in mice lethally irradiated[J]. Journal of Jilin University: Med Ed, 1988, 0(6) |
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| Authors: | Liu Ji Liu Guangjin Ling Ling |
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| Abstract: | Remarkable acceleration of hemopoietic reconstitution was observed by cotransplantation of BMC with BMSPC irradiated in vitro in varous doses into mice lethally irradiated. The experimental groups were predominant in the numbers of BMC, CFU-S and neutrophils differentiation over the con-trols, into which only BMC or unirradiated BMSPC were transplanted. The irradiated dose was found to be 10 Gy. The mechanism of the stimulating role of cotransplantation was discussed. |
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| Keywords: | Irradiation in vitro Hemopoitic reconstitution Hemopoietic stromal cells Bone marrow cells Cotransplantation Mice |
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