Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review |
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| Authors: | Yi-An Tu Yu-Li Chen Ming-Chieh Lin Chi-An Chen Wen-Fang Cheng |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University Hospital, Taipei, Taiwan;2. Department of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan;3. Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan;4. Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan |
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| Abstract: | ObjectiveTo report a case and review published cases of large cell neuroendocrine carcinoma (LCNEC) of the endometrium.Case reportA 51-year-old female presented with postmenopausal bleeding and a palpable pelvic mass. An endometrial biopsy showed a malignant mixed Mullerian tumor (MMMT). Suboptimal debulking surgery was performed. The final pathology revealed stage IVB endometrial LCNEC. Post-operative adjuvant chemotherapy with cisplatin and etoposide was administered. Two months after discontinuing adjuvant chemotherapy, salvage chemotherapy with cisplatin and ifosfamide was administered due to tumor progression; however, obstructive ileus was noted 2 months later. A segmental small bowel resection and palliative colostomy were performed. She died secondary to a post-operative infection 8 days after the operation.ConclusionEndometrial LCNEC is a rare but aggressive disease. If diagnosed, combined therapies, including staging surgery, following by adjuvant radiotherapy and chemotherapy, should be performed. |
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| Keywords: | Neuroendocrine carcinoma Endometrium Chemotherapy Radiotherapy |
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