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The cellular basis of the impaired autologous mixed lymphocyte reaction in patients with systemic lupus erythematosus. |
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| Authors: | M M Kuntz J B Innes M E Weksler |
| Abstract: | The autologous mixed lymphocyte reaction is impaired in patients with systemic lupus erythematosus. This is because nonthymus-derived (T)-lymphocyte preparations from such patients do not stimulate autologous T-lymphocyte proliferation normally. This defect may explain the impaired generation of suppressor activity in systemic lupus erythematosus and thereby the occurrence of autoantibodies in this disease. |
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