| 复合酶对离体大鼠缺血再灌注心脏的保护作用 |
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| 引用本文： | 卢彦珍,刘永明,魏蕾,涂淑珍,郑汉巧,杨海鹭,欧阳静萍,何永言,王海龙. 复合酶对离体大鼠缺血再灌注心脏的保护作用[J]. 武汉大学学报(医学版), 1998, 0(3) |
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| 作者姓名： | 卢彦珍 刘永明 魏蕾 涂淑珍 郑汉巧 杨海鹭 欧阳静萍 何永言 王海龙 |
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| 作者单位： | 同济医科大学，华中理工大学 |
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| 摘 要： | 离体大鼠心脏经低压（１．４７ｋＰａ）、无氧灌流３０ｍｉｎ后，用正常Ｋ－Ｈ液复灌３０ｍｉｎ，可导致严重的心肌缺血再灌注损伤。研究表明，复合酶可明显减轻心肌损伤，表现为能明显降低心律失常发生率，改善心脏复灌时的心率，并在一定程度上增加冠脉流量、降低心肌ＭＤＡ的含量。提示复合酶对离体大鼠心肌缺血再灌注损伤有明显的保护作用
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| 关 键 词： | 复合酶；心肌再灌注损伤；丙二醛 |
The Protective Effects of Multi-Enzymes on Isolated Ischemia Reperfusion Heart of Rats |
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| Lu Yanzhen,Liu Yongming,Wei Lei,et al. The Protective Effects of Multi-Enzymes on Isolated Ischemia Reperfusion Heart of Rats[J]. Medical Journal of Wuhan University, 1998, 0(3) |
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| Authors: | Lu Yanzhen Liu Yongming Wei Lei et al |
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| Abstract: | It was caused serious ischemia reperfusion injury on isolated rat heart, which at first flowed by Kreb’s Hensenleit(K H) buffer with lower pressure (1.47 kPa) and 95% N 2 5%CO 2 for 30 min, then reflowed by standard K H buffer with 12 kPa and 95%O 2 5%CO 2 for 30 min. The results indicated that the multi enzymes could reduce the damages of myocardium obviously: decrease the rate of arrhythmia, increase the flow of the coronary artery, and reduce the contents of MDA in myocardium. The multi enzymes had evidently protective effects on isolated ischemia reperfusion myocardium of rats. |
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| Keywords: | multi enzymes myocardial reperfusion injury malondialdehyde |
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