在严重烫伤大鼠中IL-1对葡萄糖分解代谢关键酶的调节作用

目的：探讨大鼠严重烫伤后ＩＬ－１对其骨骼肌葡萄糖分解代谢的影响。方法：利用背部３０％与一侧后肢７％ＴＢＳＡⅢ度烫伤大鼠模型，观察了伤后７ｄ内血浆与比目鱼肌中的ＩＬ－１含量及肌肉中葡萄糖分解代谢的关键酶６－磷酸果糖激酶（ＰＦＫ）和丙酮酸脱氢酶（ＰＤＨ）活性的动态变化，结果：伤后血中与比目鱼肌中ＩＬ－１水平显著升高；比目鱼肌的ＰＦＫ活性显著升高，ＰＤＨ活性显著降低。外源性ＩＬ－１静脉注射正常大鼠。注射

Regulative effects of IL-1 on key enzyme for glucose catabolism in skeletal muscle after severe scalding in rats

ObjectiveTo investigate the effects of IL-1 on glucose catabolism in the skeletal muscle aftersevere scalding in rats. Methods On the 7th d after 30% TBSAfull-thickness skin scalding on the back and 7% of the injury on one hind limb wereinflicted on rats, the content of IL-1 in the plasma and soleus muscle and the activitiesof phosphofructokinase (PFK) and pyruvate dehydrogenase (PDH) in the soleus muscle weredetermined. Results The content of IL-1 in the plasma and soleus musclewas significantly increased. The activity of PFK was markedly increased while that of PDHremarkably decreased. Conclusion IL-1 secreted from the macrophages inthe rats with severe scalding can enhance PFK activity and lower PDH activity. Therefore,IL-1 can promote glucose glycolysis and suppress glucose oxidation.