HTLV-III serology in hemophilia: relationship with immunologic abnormalities |
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| Authors: | J C Gill J E Menitove P R Anderson J T Casper S G Devare C Wood S Adair J Casey C Scheffel R R Montgomery |
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| Affiliation: | 1. Department of Pediatrics of the Medical College of Wisconsin, Milwaukee, USA;2. Blood Center of Southeastern Wisconsin, Milwaukee, USA;3. Great Lakes Hemophilia Foundation, Milwaukee, USA;4. Department of Molecular Biology, Abbott Laboratories, North Chicago, Illinois USA;1. Department of Pain Medicine, Division of Anesthesiology, Critical Care and Pain Medicine. The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States;2. Department of Diagnostic and Biological Sciences, University of Minnesota, School of Dentistry, Minneapolis, MN 55455, United States;1. Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USA;2. Department of Anesthesia, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USA;3. Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USA;1. Program of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, and University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-913, Brazil;2. Glycosciences Laboratory, Imperial College, Department of Medicine, Burlington Danes Building, Du Cane Road, London W12 0NN, UK;1. Drexel University, 1601 Cherry Street, Philadelphia, PA 19102, USA;2. Michigan State University, 308 W. Circle Dr., East Lansing, MI 48824, USA;1. Cancer Biology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, United Kingdom;2. School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, United Kingdom;3. School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, United Kingdom |
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| Abstract: | We investigated the relationship of the presence of antibodies to HTLV-III and immunologic abnormalities in patients with hemophilia. Serum antibodies to HTLV-III were analyzed by ELISA assay, immunoprecipitation of labeled cell extracts, and immunoprecipitation of purified HTLV-III p24. Thirty-four (61%) of the total group (n = 56) had antibody to HTLV-III; 34 (76%) of 45 patients given commercial factor VIII preparations were seropositive, compared with none of 11 patients treated exclusively with cryoprecipitate obtained from volunteer blood donors. Of patients who were seropositive for HTLV-III antibody, 94% had abnormal T4/T8 ratios, and 33% of those whose serum was antibody negative had abnormal T4/T8 ratios; five patients, each antibody positive, have lymphadenopathy syndrome. Sequential studies in a subset of patients indicate that there is a changing pattern of antibody production to HTLV-III antigens after seroconversion. |
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