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| 附子理中丸增强脾阳虚证大鼠适应性产热附子理中丸增强脾阳虚证大鼠适应性产热 | |
| 引用本文： | 张文通,唐汉庆,王勇,卢阿娜,赵欣,宋梦,徐雪雁,李国彰,蒋玉凤,蔡大勇. 附子理中丸增强脾阳虚证大鼠适应性产热附子理中丸增强脾阳虚证大鼠适应性产热[J]. 中国药师, 2010, 13(7): 918-921 |
| 作者姓名： | 张文通 唐汉庆 王勇 卢阿娜 赵欣 宋梦 徐雪雁 李国彰 蒋玉凤 蔡大勇 |
| 作者单位： | 1. 中国医学科学院药中国协和医科大学药用植物研究所,北京,100193;北京中医药大学 2. 北京中医药大学 3. 中国医学科学院药中国协和医科大学药用植物研究所,北京,100193 |
| 基金项目： | 国家重大基础研究项目，国家自然科学基金，教育部重点项目 |
| 摘 要： | 目的：观察附子理中丸对脾阳虚证大鼠适应性产热的增强作用.方法：18窝新生Wistar大鼠,同窝匹配、体重均衡,随机分9组,不切除甲状腺的5组为获得性脾阳虚,切除甲状腺的4组为发育性脾阳虚.d1切除部分甲状腺,d42切除肩胛骨间棕色脂肪,d56高脂饲养,d70用药防治.每周称量计算体重增长率,d98观察异丙肾上腺素诱导大鼠适应性产热的峰值（℃）和曲线下面积（℃·h）,t检验比较组间差异.结果：获得性脾阳虚大鼠,模型组与正常组相比体重增长降低37.1%（P＜0.01）,适应性产热峰值降低3.2%（P＜0.01）,曲线下面积减少3.4%（P＜0.01）.温治组与高脂组相比,体重增长增加33.6%（P＜0.01）,适应性产热峰值升高0.5%（P＜0.01）,曲线下面积增加0.7%（P＜0.01）.发育性脾阳虚大鼠,模型组与正常组相比体重增长降低16.6%（P＜0.01）,适应性产热峰值降低5.5%（P＜0.01）,曲线下面积减少5.6%（P＜0.01）.温治组与高脂组相比,体重增长降低58.8%（P＜0.01）,适应性产热峰值升高1.1%（P＜0.01）、曲线下面积增加0.9%（P＜0.01）.结论：附子理中丸增强获得性和发育性脾阳虚模型大鼠的适应性产热. |
| 关 键 词： | 附子理中丸 脾阳虚证 大鼠 适应性产热 |
Aconitum Lizhong Pill Strengthening Adaptive Thermogenesis in Rats with Spleen Yang Deficient Syndrome |
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| Zhang Wentong,Tang Hanqing,Wang Yong,Lu Ana,Zhao Xin,Song Meng,Xu Xueyan,Li Guozhang,Jiang Yufeng,Cai Dayong. Aconitum Lizhong Pill Strengthening Adaptive Thermogenesis in Rats with Spleen Yang Deficient Syndrome[J]. China Pharmacist, 2010, 13(7): 918-921 | |
| Authors: | Zhang Wentong Tang Hanqing Wang Yong Lu Ana Zhao Xin Song Meng Xu Xueyan Li Guozhang Jiang Yufeng Cai Dayong |
| Affiliation: | Zhang Wentong~(1,2),Tang Hanqing~(1,Wang Yong~2,Lu Ana~(1,Zhao Xin~1,Song Meng~2,Xu Xueyan~2,Li Guozhang~2,Jiang Yufeng~2,Cai Dayong~(1,2)(1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100193,China,2.Beijing University of Traditional Chinese Medicine) |
| Abstract: | Objective:To observe the effect of Aconitum Lizhong pill on the adaptive thermogenesis in rats with spleen yang deficient syndrome.Method:Eighteen litters were used in this experiment.Nine littermates in each litter were bred sequentially and randomized into 9 groups.Five groups were not carried out thyroidectomy,the other four groups did.Thyroidectomy in hypothyroidism littermates was carried out with iodine to destroy partly thyroidal tissue at d_1 after birth,the interscapular brown adipose tissue was re... |
| Keywords: | Aconitum Lizhong pill Spleen yang deficient syndrome Rats Adaptive thermogenesis |
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