| 二甲基甲酰胺对肝脏钙稳态影响的实验研究 |
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| 引用本文： | 阚宝甜,乔赐彬. 二甲基甲酰胺对肝脏钙稳态影响的实验研究[J]. 中国公共卫生学报, 1997, 0(3) |
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| 作者姓名： | 阚宝甜 乔赐彬 |
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| 作者单位： | 山东医科大学附属医院内科(阚宝甜)，山东省劳动卫生职业病研究所(乔赐彬) |
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| 摘 要： | 采用二甲基甲酰胺短期染毒实验方法观察了它对肝脏钙稳态的影响。结果表明，二甲基甲酰胺可明显降低线粒体、微粒体对钙离子的转运能力，抑制Ｃａ２＋－ＡＴＰａｓｅ活力，使胞浆中钙离子浓度升高。病理及超微结构观察示它可致肝细胞损伤甚至坏死，其损伤的主要部位在线粒体及内质网。
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| 关 键 词： | 二甲基甲酰胺 肝脏 线粒体 微粒体 钙稳态 |
Expermental Investigation of Dimethylformamide on Calcium Homeostasis of Rat Liver |
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| Jian Xiangdong,et al.. Expermental Investigation of Dimethylformamide on Calcium Homeostasis of Rat Liver[J]. , 1997, 0(3) |
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| Authors: | Jian Xiangdong et al. |
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| Affiliation: | Jinan 250012 |
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| Abstract: | In this paper short term Dimethylformamide administration was used to observed the influence of Dimethylformamide on rat liver calcium homeostasis.The result showed that Dimethylformamide could decrease the ability of Ca 2 transport by mitochondria and microsome,inhibited the ativity of liver Ca 2 ATPase and increared the activity of phosphorylase a.Pathological and ultrastructure observation showed that Dimethylformanide could cause rat liver cells parenchymatous degeneration and necrosis.Mitochondria and microsome were damaged seriously. |
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| Keywords: | Dimethylformide Liver Mitochondria Microsome Calcium homeostasis |
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